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Showing content with the highest reputation on 11/08/2023 in all areas

  1. I guess I feel like it's potentially valuable to mention Dr. Schindler's finding from the Yale study of psilocybin and CH. I only have access to the summary information, and there might be more that I need to know, but the report (https://headachejournal.onlinelibrary.wiley.com/doi/abs/10.1111/head.14420) states: >>>Changes in cluster attack frequency were not correlated with the intensity of acute psychotropic effects during psilocybin administration. The separation of acute psychotropic effects and lasting therapeutic effects underscores the need for further investigation into the mechanism(s) of action of psilocybin in headache disorders.<<< I read this to mean either that any form of tripping is unrelated to treating CH, or that a lesser "trip" or psychedelic experience is just as likely to have therapeutic effects as a stronger experience. I think this has been pretty well understood here for a long time, and that in general trip-level doses are recommended not because they are therapeutic in themselves but principally because they ensure that a person has ingested enough psilocybin. (Whether a trip is necessary for other benefits, such as overall anxiety reduction and better overall sense of well-being, I don't know.) At the same time, I feel like seeds are possibly dismissed sometimes because there is no trip -- because it doesn't seem like a bold enough response to the horror of CH. And sometimes people are encouraged to "trip balls" or "see God" if lower doses aren't working. Neither of these approaches would seem to be consistent with what Schindler reports. (Of course, she could be wrong, and also, since the highest dose in her study was equivalent to about 1.25 grams, maybe the study's results would have been better if people had taken more (and correlatively probably had stronger trips).)
    2 points
  2. So 2 weeks out from the last infusion day and still feeling much better that before I had this done. I am still getting hit 1 to 3 times a day but they are MAYBE a 3 on the cluster scale and last only 5 to 10 minutes most with using oxygen. I have only had 1 5Hour energy drink in the last 2 weeks and am still on the same M60 tank so that itself is a big help in the pocket. I am thinking about tossing a bust or 2 into the mix next week just to see if I can get this knocked out totally for a few days but am a little nervous that I will F something up and fall back into hell again. Currently getting the little hits overnight and it still sucks to wake up and hit the 02 tank but I can deal, I can work and get a tun of things done during the day again. So far I am pleased and would recommend but I have not gotten the bill or know how long this will last yet so that may change my mind..
    1 point
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