Bejeeber

Article: Transforming psychedelics into mainstream medicines "......research has revealed that some psychedelics that activate the serotonin 2A receptor are potently anti-inflammatory at doses unlikely to result in psychoactivity."

I guess time (with more research, more experimentation) will tell. Meantime, there's this from https://www.verywellhealth.com/micro-dose-lsd-5077103: "....People with chronic pain diseases such as fibromyalgia, lupus, and rheumatoid arthritis may, according to researchers, benefit from extremely low doses of lysergic acid diethylamide (LSD or "acid").."

I'll suggest those of us in busting mode could start thinking about and noting whether we've experienced other anti-inflammatory benefits. This could just be coincidence, and an account from one lone dude is as anecdotal as it gets, but personally I'm slap-happy to report that following the past couple busts, I've had inflammation symptoms such as lower back pain go poof.

Drewbie, I'm going to guess here that you are actually NOT "one biological flick of a switch away from full blown cCH", but of course I realize strong anxiety can make it convincingly feel like you are. Besides encouraging you to continue to rigorously adhere to the D3 regimen, I'll just repeat what I've reported in other threads in this forum, even though busting may not be advisable, and could present sourcing challenges for you: I found busting not only helped quash some entire CH cycles for me, but it long term quashed my CH related PTSD-like symptoms (basically anxiety/fear/dread). Ironically during some of my busting sessions, I experienced very heightened anxiety, so I now advocate a diazepam type tranquilizer while busting for anyone prone to anxiety (but not such medication for daily non-busting induced anxiety). And for a good while now there have been the reports like this about how A single dose of the psychedelic compound found in so-called magic mushrooms has eased anxiety and depression for a group of cancer patients for more than four years. Not that we are cancer patients. You mentioned how exceptionally physically active and fit you were prior to this difficult bout - since exercise is also really supposed to be good for relieving anxiety, I hope you can find a way to get back to it soon and start enjoying its benefits again. FWIW there's also this bit I found interesting about a new testosterone spray to treat anxiety disorders. All this said, if I was facing an unrelenting bout with imitrex effectiveness waning, I'd have to assume I'd find myself right back in the heavy dread zone. Sorry to hear your nerve block was delayed this time around, with things going full blown while waiting, but glad to hear that at least the nerve block has had some real effectiveness.

And drewbie, completely agreed with your take on the subject too.

Excellent elucidation of this BOL spectacle and all the nutty baloney surrounding it CHfather, thank you.

Whoa - wouldn't that be incredible if someone was actually able to get BOL-148 fully approved, manufactured and available for prescription? For that matter over the counter availability would be fine with me . To see this non-hallucinogenic version of LSD, reputedly much more effective for CH, finally become available could be such a game changer, and such a longer than lonnnnnng time coming after it it's promise has been known for so many years, with the maddening (and then some) history of false starts.

I was kind of going off topic a bit over at DMT - First time finding an effective abortive, so I'm moving my tangent touting psychedlics as anti-inflammatories over here. If I understand correctly, the anti-inflammatory effect of psychedelics is thought to be mediated through the serotonin 5-HT2A receptor. Article - Psychedelics as Anti-Inflammatory Agents Article - "Research has shown that psychedelics, such as lysergic acid diethylamide (LSD), have profound anti-inflammatory properties" Article - Scientists identify a powerful anti-inflammatory compound in psychedelic drugs

Hi A-Z, I remember reading way back that benzo withdrawals can cause severe suicidal depression, not sure if the source was scientifically legit or what though. Plus it sounds like you're pretty much over the benzo withdrawal side effects by now. Modern day cannabis, bred to be super strong, gives me anxiety and some paranoia, so I don't imbibe. Not sure if it's just a change in my biochemistry or what, but the old, much milder, 70's style cheap "commercial" weed in California never triggered any of that for me. Quite the opposite, in fact, it was relaxing and mellowing. The following are not suggestions so much as stuff I find interesting on the subjects in this thread: Depression: I was going through a questioning existence phase there for a bit. Mighta just been mid-life crisis that was about to end anyway, but around that time I started (successfully) busting with vitamin M for CH, and it not only removed my CH related PTSD-like symptoms, but I also found myself in a better, non existential crisis sort of head space. Of course it's all over the news as of late about psilocybin treatment for depression, and for someone in Oregon, or who could go there, I find the whole thing about Oregon will become the first state to formally legalize the medical use of psilocybin to treat mental health conditions in licensed facilities using registered therapists interesting and encouraging. I'm already thinking about trying to get a relative to head there for such treatment when available and possible. I would stop short of encouraging people to try to wing it with DIY psilocybin for depression therapy though. Panic attacks: I have to wonder if the cannabis could really be a culprit 15 days after the fact? Meantime I found this bit about a new testosterone spray to kill panic attacks seriously intriguing. It sure sounds to me (someone who doesn't even resemble a doctor) like you've experienced some manner of lasting biochemical imbalance induced by a substance intended to be therapeutic for CH, that you can and will regain the balance you were enjoying previously, at which point you'll be so over these side effects, and will be golden.

My only experience with running and CH involved bursting into an all out sprint (or rapid running in place) in an occasionally successful attempt to abort an impending attack. It really only worked a couple times for me when I was in the less intense initial part of a cycle though, it's level of effectiveness for me was similar to breathing freezing cold air.

Kat I'd suggest it doesn't almost seem like you need a headache specialist type neuro as opposed to the garden variety type, more like you definitely do, based on your experience and that of zillions of other CHers.

Vader, I hope in your research you've at least become encouraged that there are treatments for CH, such as are outlined in CHfather's overview link, and also touched on by FunTimes above. Some of us really do find significant relief, and while there can be a bit of luck involved regarding who is going to respond to what, my money is on you finding your way there too.

+1 for what an excellent and moving video that is.

I guess you could say sleep is an extremely common trigger, maybe number one. From my personal experience and what I've seen others mention, I'd say alcohol is way up there too. I still tend to believe that some can age out of CH, especially after having seen an extensive long running survey (Scandinavian I think) years ago, where this was tracked and "confirmed", but how many of those who have aged out and haven't had a cycle for at least a decade are likely to seek out an online message board to discuss it? So far I think it's been zero. Actually I guess you never really know you've 100% aged out for sure until you're dead, right!!?? In the highly anecdotal realm I did meet a retired law enforcement officer CH'er, 60+ years of age, who was planning to bust with psilocybin if another cycle were to ever hit, but it had been 10 years since his last cycle and he felt there was a strong chance he had aged out.

Ugh. Sorry to hear this about your CH'er Anita. I'm aware of rare instances where a pred burst has knocked a cycle out, but all too often following some days of relief from a burst, the CH comes back with a vengeance, something I've personally experienced and seen many others also report. Hoping you both can escape the war zone ASAP and find some peace.

Jimmy, I believe Twisted-M makes a valid point, in that those of us who've spent years on end observing, discussing and experimenting with CH treatments have seen certain ones have proven to be most effective and work for an impressive percentage of headbangers, and the magic, AKA "psilocybin busting", T-M speaks of is known to be a powerful preventive, the most effective preventive for plenty of us. I'll personally vouch for it's effectiveness, as could thousands of others at this point I believe. With you right on the verge of a cycle coming to an end (I'm hoping!), I'm not sure whether you could get set up with it before the CH is gone, but I think it's something to keep high on the radar in general, while also keeping in mind the contra-indications regarding family history of schizophrenia, etc. Now RC (Rivea Corymbosa) seeds, a psychoactively milder busting substance, are legal to quickly purchase online and to possess, but not ingest, and some have had success with them.

Good one Spiny.

My impression is that major stress, such as divorce, financial disaster, loss of home, job, etc. can trigger a cycle in an already prone CH'er, basically the worst times imaginable to be hit with a cycle can be the most likely. Plenty of headbangers have reported the same about weather changes for sure. As far as individual attacks within a cycle are concerned though, "stay stressed" has actually been a popular refrain, since relaxation in the form of sleep, naps, weekends, etc. is known to be a strong trigger. This would be a much less traumatic level of stress of course. I tend to think "stay engaged" can be a better, still effective way to try to operate.

Hi Jimmy, I know a chiropractor who is a long time CH'er, and who has been very involved with this site. He doesn't find chiro to be of help with CH, and the same conclusion has been come to by plenty of other headbangers. Bleach fumes can be a trigger for me and others, if the swimming pool was chlorinated, I wonder if that could have played a part? The neck issues are common. You probably won't be surprised to hear someone like me say it's difficult to define a typical length of an attack. Maybe that's because my personal experience has seen them gradually go from 20-ish minutes to more like 3 hours over the decades. It sounds to me like you could still adopt a more effective O2 dispensing strategy than your current approach, and it could make a big difference. If you're going to continue to go with triptans, imitrex injections may be your best ins. co paid bang for the buck - only 2 syringes of it may be covered a month, which sux bad, but the doses can be split so you can get 3 aborts from one syringe, so at least you get 6 aborts total. And the shots are known to be the quickest, most effective method of delivery.

Hi JimG, Sounds like 17 years in, your CH had a pretty established pattern of behavior. The weird thing is, it turns out it's common to be hit with a pattern shift you never would have expected, even after umpteen years of predictability. One of the most common shifts is the lengthening cycles BTW, so It's probably not worth worrying about chronic for another few months at least. Lotsa headbangers are convinced the usage of triptans can cause cycles to lengthen. I've been episodic for going on 37 years, so I had 12 years or so of CH joy before triptans hit the market in the US, and what I found was my cycles kept lengthening and lengthening before I ever tried a triptan. I had been on some heavy cocktails of other prescriptions though. Here's hoping you'll be 12-ish weeks and done this time, with a sudden cessation, or at least you'll see it tapering off soon, which I figure is a likely scenario. I'll officially place a bet on that right now.

Hi Jimmy, A lot of us around here would agree your specialist made the right call about topomax being too heavy. Many have come to refer to it as Dope-a-max, Dopey-max, etc., and find it messes with the cognitive processes way too much, plus it isn't that effective. For CH'ers who are typically awakened with an attack an hour or so after falling asleep, I've seen reports of an oral triptan before bed working as a preventative, so I guess I shouldn't be too surprised to see the frovatriptan being prescribed in that manner. Maybe you've started researching busting at this point? It has the potential to knock out entire CH cycles, which can be nice. You have to be "de-toxed" from triptans for 5-ish days before trying it though. I had an acupuncturist do a great job of rapidly ridding me of some tendonitis in a wrist before, so I'm a believer, but I'm sorry to tell ya it has scored low when it comes to directly treating CH.

Hi Anita, CHf just dished out some great, critical Info IMO.

Interesting perspective Jon, thanks. Agreed with Spiny on how common it is for episodics to fear they're going chronic, often when we're really not. Also, cycles can elongate for some of us episodics as the years with CH go by. Maybe it can ease the mind a little to know that this isn't so unusual, and doesn't necessarily indicate we're on the verge of going chronic.

Hi Jimmy - I see Dallas Denny and Spiny just double teamed you, which is fantastic luck, as they are veteran CH'ers with tremendous knowledge of the most effective CH therapies. Me, I've been episodic for 37-ish years, with some long remissions at some points, and like DD and Spiny, years of poring over reports from our fellow headbangers, along with lots of CH discussion. I'm in agreement with all the input you've received so far.

Hi Jacob, hate to hear the CH is still relentless for you, but glad to see you continue to get excellent advice here. Many other headbangers have also reported looking back to when they had been recreationally tripping and realizing they'd been CH free during that time period. In your case, it seems it could be a positive indicator that busting could work for you. You'll want to be aware that triptans like Zomig are known busting "blockers" and should be avoided for 3 to 5 (depending on who you're talking to) days before busting.