CHfather Posted July 17 Share Posted July 17 NY Times, "Taking the Magic Out of Magic Mushrooms" https://www.nytimes.com/2022/07/15/opinion/hallucinations-psychedelics-depression.html A couple of themes in this story (and nothing about CH), but the one that interested me: "some scientists are working to develop molecules based on psychedelics that provide the therapeutic benefits of the drugs but without the hallucinations." 2 Quote Link to comment Share on other sites More sharing options...
Shaun brearley Posted July 17 Share Posted July 17 Some scientists are working to develop molecules based on psychedelics that provide the therapeutic benefits of the drugs but without the hallucinations God I hope not only joking would be an amazing thing if they can 2 Quote Link to comment Share on other sites More sharing options...
xBoss Posted August 13 Share Posted August 13 I never hallucinate regardless of the dose or if it's shrooms or LSD. I did a couple times about 25 years ago and then it was over. Quote Link to comment Share on other sites More sharing options...
Bejeeber Posted August 14 Share Posted August 14 Interesting article indeedy - I had seen it too, and had been 'planning' on posting it here. Once again @CHfather beats me to the punching festivity. Quote Link to comment Share on other sites More sharing options...
Bejeeber Posted August 14 Share Posted August 14 On 7/16/2022 at 11:30 PM, CHfather said: some scientists are working to develop molecules based on psychedelics that provide the therapeutic benefits of the drugs but without the hallucinations I noticed there was a conspicuous absence of mention of BOL-148 though. Quote Link to comment Share on other sites More sharing options...
AlanK Posted August 14 Share Posted August 14 14 hours ago, Bejeeber said: I noticed there was a conspicuous absence of mention of BOL-148 though. Interesting article from May. Talks about Cluster and Migraine https://psych.global/ceruvia-lifesciences-on-lsd-and-bol-148/ 1 Quote Link to comment Share on other sites More sharing options...
Bejeeber Posted August 14 Share Posted August 14 44 minutes ago, AlanK said: nteresting article from May. Talks about Cluster and Migraine https://psych.global/ceruvia-lifesciences-on-lsd-and-bol-148/ "....with BOL-148 we have to conduct an ascending dose Phase I trial, which we’ll be starting next quarter. We plan to share top line data from the study in the first quarter of next year, and then we’ll move straight onto Phase II..." So highly appreciative that this is occurring, while also remaining exceptionally jaded (after so many false starts and disappointments) regarding the question of whether we will ever get our hands on this non hallucinogenic super LSD / super busting substance that has clinical trials dating back to the 1950's. 2 Quote Link to comment Share on other sites More sharing options...
AlanK Posted August 14 Share Posted August 14 3 minutes ago, Bejeeber said: "....with BOL-148 we have to conduct an ascending dose Phase I trial, which we’ll be starting next quarter. We plan to share top line data from the study in the first quarter of next year, and then we’ll move straight onto Phase II..." So highly appreciative that this is occurring, while also remaining exceptionally jaded (after so many false starts and disappointments) regarding the question of whether we will ever get our hands on this non hallucinogenic super LSD / super busting substance that has clinical trials dating back to the 1950's. I checked clinicaltrials.gov to see if it was listed. Nothing there, guess not ready to announce officially or it's private? I'd be happy to get a compound that acts like L but with the duration of MM. 1 Quote Link to comment Share on other sites More sharing options...
jon019 Posted August 14 Share Posted August 14 ...another article of interest x/migraine again website Can LSD and Magic Mushrooms Treat Migraine and Cluster Headache? — Migraine Again 3 Quote Link to comment Share on other sites More sharing options...
Lindsey P Posted August 19 Share Posted August 19 My partner was diagnosed years ago and was not provided any help. He has gone from episodic to chronic in the last 2 years having only had a few week at best of relief. He's up to 2-3 a night and some during the day if he tries to sleep at all. So my question is, other than driving to CA or CA, where can we obtain the magic mushrooms? He's got an appointment finally at a headache clinic in Houston next week, but after trying most things, he's desperate. As a spouse that often wakes up when he does, I am too. Quote Link to comment Share on other sites More sharing options...
jon019 Posted August 20 Share Posted August 20 (edited) ....has he tried hyperventilating OXYGEN at the VERY FIRST sign of a hit... with a non rebreather mask at 15-25+ liters per min with an energy drink of at least 120 mg caffeine/1000 mg taurine? a 2 oz 5-hr energy type goes down quick and can abort on its own....for me it made oxygen faster and more effective... ...any prevents like verapamil?... ....any prednisone/prednisolone iv and/or taper to break a cycle til a prevent kicks in?... ...abortives like imitrex or zomig nasal spray?... ...diet analysis to eliminate alcohol, nitrates, msg, aspartame, personally specific triggers?... ...stress reduction measures...? stress can be either a prevent or a trigger... ....active physical exertion ? (abortive for some, trigger for others).... ...vitamin D3 regimen?.... give us any details you can think of and any measures tried and we'll try to help... . Edited August 20 by jon019 Quote Link to comment Share on other sites More sharing options...
Lindsey P Posted August 20 Share Posted August 20 21 hours ago, jon019 said: ....has he tried hyperventilating OXYGEN at the VERY FIRST sign of a hit... with a non rebreather mask at 15-25+ liters per min with an energy drink of at least 120 mg caffeine/1000 mg taurine? a 2 oz 5-hr energy type goes down quick and can abort on its own....for me it made oxygen faster and more effective... A: He does Expresso or strong coffee to abort. Worked well the first few weeks then started getting rebounds before he even got to sleep again. ...any prevents like verapamil?... No. He was afraid of going back to the doctor just to be told he couldn't be helped. ....any prednisone/prednisolone iv and/or taper to break a cycle til a prevent kicks in?...No. He has essentially stopped cycling. ...abortives like imitrex or zomig nasal spray?... Has done nasal spray, did not mitigate or abort ...diet analysis to eliminate alcohol, nitrates, msg, aspartame, personally specific triggers?... Total elimination of alcohol as that was a definite trigger. He is to a point of being afraid to live and work. Down to not wanting to eat because hes afraid of it being a trigger. ...stress reduction measures...? stress can be either a prevent or a trigger... We just moved the second time in 2 years along with his job. I work remotely for the most part so document everything. ....active physical exertion ? (abortive for some, trigger for others).... He could defintily do better. When the weather is reasonable in texas, we'll paddleboard and walk trails. ...vitamin D3 regimen?.... Just started... I will be reminding him daily to take. give us any details you can think of and any measures tried and we'll try to help... . Quote Link to comment Share on other sites More sharing options...
jon019 Posted August 21 Share Posted August 21 .....the first words out of a proficient headache specialist doctor once he/she diagnoses CH should be: "here's a script for oxygen"...saved my sanity, perhaps life. no side effects, no rebounds, fast, cheaper than triptans, easy once you figure set up and the right breathing techniques, way more portable than stereotype implies. kept a job and career 31 yrs by bringing e-tanks (in cart) to work (office, car) and larger m-60 at home. even successful busting may require use for slapbacks and occasional breakthroughs... ....the high caffeine for abort works sometimes for some...i needed the caffeine plus taurine of the 2-hr energy drink type mostly to improve the oxygen effectiveness, making sure to avoid caffeine at all times except to abort. my experience that no rebounds or sleep interruption...tho caffeine was a trigger in between normal hit times.... ...if you are interested there are multiple threads on verapamil usage...just type in search bar. i had fairly good success reducing hits and intensity for seven yrs while titrating dosage to match place in cycle... ...a food log can help narrow those triggers...besides alcohol i only had 2, aspartame and msg (determined this way). note that msg comes in MANY versions...do a google search (anything hydrolyzed, autolyzed, tvp, yeast extract, yadda yadda). see "migraine diet"...doesn't necessarily apply to CH but there are some clusterheads who benefit by avoiding nitrates, glutamates, tyramines (beer, cheese, fermented foods)... ....injectable triptans more effective for most...tho the 6 mg statdose is WAY too big a hammer...most find 2 mg sufficient using imitex vials or hacking the statdose and using an insulin needle. goal is ONLY as last resort abort when all else fails. after successful busting is likely not needed at all .... ...whether staying in an active lifestyle or not made no difference for me. but, some find immediate strenuous exertion at first sign of a hit.... like running or exercises or any aerobic to be a good abort tactic. oddly, a trigger for others... ...be sure to get baseline blood tests per the D3 regimen...you need to know where you are starting from and what levels gets to pain free... ....finding a good busting regimen could make all the above moot....tho the D3 regimen is good for ya whether CH or not... jon Quote Link to comment Share on other sites More sharing options...
mit12 Posted September 7 Share Posted September 7 This would be so awesome for the people that suffer with this horrible condition. Magic Mushrooms give me the worst side effects, my body temperature spikes than drops and I get severe buzzing that is almost unbearable. This keeps me from taking them until I am desperate for relief. We have been given the “right to try” for people with a life ending illness, wouldn’t it be great if we could get the right to try for Clusters! I would do BOL-148 in a heartbeat if I could get it. Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You can post now and register later. If you have an account, sign in now to post with your account.