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xxx

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Everything posted by xxx

  1. Hey Henrithree, Thank you for the wonderful feedback on your response to this vitamin D3 regimen and the kind words. You need to understand this regimen is just a preventative and not a one-time, single-shot cure for CH. In order to enjoy its many healthy benefits and CH free quality of life, you'll need to take it daily year round... even if you're episodic. Data we've collected since December of 2010 indicate adults on this regimen burn serum 25(OH)D at a rate of roughly 14 ng/mL/month (35 nmol/L/month). That means if you have a 10 ng/mL (25 nmol/L) reserve above the tipping p
  2. xxx

    New Med

    Hey M, Great question. As long as I'm at a stable vitamin D3 dose, I'll have labs for 25(OH)D, calcium and PTH done once a year a week prior to my annual physical so my PCP and I can discuss the results. I usually have all the other labs needed for my annual physical done at the same time. If I've needed to raise or change the vitamin D3 dose to counter problems associated with an allergic reaction or surgery, I usually wait at least a month following the dose change then go in for the same three labs. Hope this helps. Take care and please keep us posted. V/R, Batch
  3. xxx

    New Med

    Hey CoryAnn, Your husband is on the right track taking the anti-inflammatory regimen with 10,000 IU/day vitamin D3 and the conutrients to control his CH. The success rate for this regimen based on the results from the online survey of 257 CHers who started this regimen to control their CH over the last 8 years follows. 80% of CHers starting this regimen experience a significant reduction in the frequency of their CH from an average of 3 CH/day down to 3 to 4 CH/week in the first 30 days. The response rate improves over time as some CHers take up to 3 months to respond to this regimen.
  4. Hey Dana, The answer is Yuppers! This diet works great to prevent all kinds of migraine and cluster headache... It also gets rid of jiggles in places that shouldn't jiggle and turns people into hard body good lookers. It works great on my 74 year old frame... I lost so much around my middle I had to switch to braces to keep my drawers up. My wife isn't complaining either... Take care and please keep us posted. V/R, Batch
  5. Hey Milelli, You're spot on! There's a good reason why the mAb RCTs can't achieve better efficacy in preventing CH and MH. When you consider the site of action are neurons within the brain that express calcitonin gene-related peptide (CGRP) and other nasty peptides that trigger CH and MH. The mechanism of action espoused by Big Pharma is neutralization of CGRP. Accordingly, the first step in this process is getting the anti-CGRP mAb into the brain. That's a very real problem Big Pharma has yet to solve. The maximum opening size through the tightly packed endothelial cells
  6. Hey Spiny and Pebbles, Thanks for the plug with kind words about the D3 Regimen efficacy. After reading the article on galcanezumab-gnlm (Emgality) results when treating episodic CHers... all I can say is bless my long gray whiskers, the author of this article and the folks at Lilly who paid for this RCT must have been thinking pure thoughts. Here's my analysis of the results. BTW, I've read the results from all the anti-CGRP monoclonal antibody RCTs for episodic migraine and episodic cluster headache... The published results of these RCTs tend to sugar coat the absolute efficac
  7. Hey DM, In the days before I developed and started taking the anti-inflammatory regimen with 10,000 IU/day vitamin D3 (2005-2010), I drove to work and back home with my M60 on the floor behind the drivers seat daily driving 25 miles up 395 to the beltway to McLean, VA . I configured my M60 with an InGage® 0-60 liter/min regulator from FlotecO2 and oxygen demand valve. If I got hit while driving, I pulled over to use it. That made for some interesting discussions with the State Patrol when they pulled in behind me to see why I was stopped along the freeway... If your CH are hi
  8. xxx

    Topamax?

    Henri, Your feelings are correct... Many of us who have tried Topamax refer to it as Dopeymax as it leaves you in goofy state and doesn't do much to prevent CH. Take care and please keep us posted. V/R, Batch
  9. Hey Stephan, That's a very healthy list of natural nutrients... Add 10,000 IU/day vitamin D3, 400 mg/day magnesium (chloride or glycinate), a mature multi with zinc and boron, 1000 to 2000 mg/day Omega-3 fish oil and a good vitamin B complex and you'll have a fantastic natural CH preventative regimen that will let you drink beer, wine and other spirits without a hit. A change in diet to a ketogenic or Atkins diet with zero sugars, zero wheat products and only limited amounts of carbohydrates plus 2.5 liters of water a day will also be a big help. You can eat all the free range organic
  10. Plhbn, Great questions. The vitamin D3 dose for children I've been using for my grand kids over the last 8 years is 50 IU per pound of body weight per day. If you're using the metric system it's 110 IU per Kg body weight per day. This is a very safe and conservative dose so you can round up or down to the nearest 1000 IU. For girls age 78 months, the 50th percentile weight is around 47.3 lbs or 21.5 Kg so the calculated dose would be 2,300 IU/day. In this case a vitamin D3 dose of 2000 IU/day will be just fine. My grand kids also take a multi-vitamin daily with magnesium, zinc, the B
  11. Hey Plhbn, I trust you're still CH pain free. Boron, like the other conutrients in the anti-inflammatory regimen, supports vitamin D3 pharmacokinetics, (what the body does to vitamin D3) and pharmacodynamics (what vitamin D3 does to the body). For example, magnesium, zinc and boron support the enzymatic processes that hydroxylate vitamin D3 to 25(OH)D3 and further hydroxylate 25(OH)D3 to 1,25(OH)2D3, the genetically active metabolite. These enzymatic processes take place in two domains, the bloodstream and at the cellular level throughout the body. What happens in the bloodstrea
  12. Henri, Thank you for the kind words and wonderful feedback on your experience with the anti-inflammatory regimen. Many of us know the exciting feeling waking up in the morning knowing you've slept through the night CH pain free. There are a few things you need to know in order to maximize the CH preventative capability of this regimen. For starters, its a CH preventative, not a cure. Accordingly, you'll be best served by taking this regimen year round. Most of us do this as a way of life... Staying on this regimen year round will accomplish two things. The first is you'll likel
  13. The Flu season is here... For CHers taking the anti-Inflammatory regimen with 10,000 IU/day vitamin D3 and conutrients, you're in good shape with a very low probability of catching the flu. For the rest, 5,000 IU/day to 10,000 IU/day vitamin D3 plus at least 400 mg/day magnesium should provide enough to supercharge your immune system to ward off the flu bug. People with a low vitamin D3 status as measured with the 25(OH)D lab test <30 ng/mL (75 nmol/L) will benefit most. The really important benefit of taking vitamin D3 to prevent the flu is there are no adverse side effects... You
  14. Hey Big J, Benadryl works best to block the histamin H1 receptor when it's vacant. If histamine molecules have already occupied available H1 receptors, usually characterized by a CH... the Diphenhydramine will be useless. Moreover, the histamine triggers the expression of CGRP and SP, both of which are responsible for neurogenic inflammation and the pain we know as CH. The only way around this is to take 25 mg Benadryl (Diphenhydramine HCL) every 4 hours during the day and hopefully during a CH pain free period. This allows the Diphenhydramine to pass through the blood brain barr
  15. Hey Bilal, Thank you for the wonderful feedback on your experience with the anti-inflammatory regimen. Knowing you're CH pain free is exactly how this regimen is meant to work. Take care and thanks again. V/R, Batch
  16. xxx

    Skin pain

    Siegfried, A lot has happened in the field of molecular biology in the last 15 years since the two studies you referenced were conducted. For example, sequencing of the human genome was largely complete in 2003 and finally completed with the sequencing of the last chromosome in 2006. Since then there's been an explosion in the area of genetic mapping tools and today you can find several credible sites offering gene atlas like BioGPS that illustrate the distribution and density of specific genes. Where all this applies to cluster and migraine headache takes us to the central dogma o
  17. xxx

    Skin pain

    Hey Siegfried, Thanks for the two links. They make a lot more sense saying that once a migraine headache progresses to the point of cutaneous allodynia, triptans become far less effective as an abortive. This jives with with the side effects of a CGRP cascade where both CH and MH become so severe in frequency, pain and duration, nothing works... Thanks again, V/R, Batch
  18. Hey Big J, Good questions... but bad move if you drop your vitamin D3 dose to 5000 IU/day. I'll explain... The average adult burns through roughly 5,000 IU/day vitamin D3... if its available. Each sustained dose of vitamin D3 results in a time course 25(OH)D response where the 25(OH)D serum concentration reaches a stable equilibrium. The following chart developed by Dr. Robert Heaney, MD, illustrates what I'm talking about. As you can see, a maintenance dose of 5000 IU/day and resulting 25(OH)D serum concentration puts you on the ragged edge of the green zone where CHers hav
  19. Hey Big J, Sorry to be so slow. Still shoveling snow off the driveway that fell last weekend... Great question. It turns out that bacterial and viral infections, allergic reactions, trauma and surgery all result in a drop in serum 25(OH)D concentrations. This drop can be as much as 70% for surgery and trauma. If you're taking enough vitamin D3 to keep your serum 25(OH)D above the tipping point that keeps you CH pain free and experience one of the above conditions, you'll get whacked! Accordingly, the answer to your question is YES. You will need to up or bump your vitamin
  20. xxx

    Skin pain

    Hey Siegfried, That's a new one on me... sounds more like the classic chicken or the egg conundrum... which comes first... The most common reason why triptans become ineffective other than overuse, is the flood of histamine released from mast cells during allergic reactions. The histamine triggers neurons within the trigeminal ganglia to express calcitonin gene-related peptide (CGRP) and Substance P (SP). CGRP and SP are the two nuroactive peptides found elevated in serum concentrations during the pain phase of CH and MH. They are responsible for the neurogenic inflammation and pain
  21. xxx

    Skin pain

    It's called cutaneous allodynia... The perception of pain when a non-noxious stimulus is applied to normal skin. It's a common symptom of migraine and cluster headache syndromes.
  22. xxx

    Tinnitus

    The best supplements for controlling tinnitus include: Ginkgo Biloba, B Vitamins: Niacin, Thiamin and Vitamin B12; Zinc, Magnesium and vitamin D3. There are several studies that found these supplements effective in controlling tinnitus. You get everything but the Ginkgo Biloba in the anti-inflammatory regimen CH preventative treatment protocol at the following link: http://www.vitamindwiki.com/tiki-download_wiki_attachment.php?attId=7708 I also add Quercetin. Take care, V/R, Batch
  23. Complain to Congress you say. It is bought off. A reported army of 1440 lobbyists for the pharmaceutical industry is in Washington DC. The pharmaceutical industry spend $280 million on lobbying Congress in 2018. That amounts to a half-million dollars per member of Congress. BOUGHT OFF: Why You Don’t Hear About Low-Cost Natural Remedies In The News
  24. Dental work is a double edged sword for CHers. While some may find the anesthesia a trigger, the infection associated with dental cavities and gingivitis causes the release of neuroinflammatory agents that trigger CH in most CHers even if taking 10,000 IU/day vitamin D3. After 8 years collecting feedback data from CHers taking the anti-inflammatory regimen and lots of research, it's best to maintain good dental health with checkups and cleaning at least every 6 months.
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