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xxx

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Everything posted by xxx

  1. There are 4 RCTs registered in cinicaltrials.gov using mAbs (monoclonal antibodies - 3 for Fremanezumab and one for Galcanezumab) as the intervention for CH and more are likely to follow. Three of the mAbs tested with migraine had an appetite for calcitonin gene-related peptide (CGRP) and a fourth that plugs the CGRP receptor. IMHO... the use of mAbs is still focused on the treatment of symptoms (neurogenic inflammation and the pain caused by CGRP) and not on one of the underlying causes. If you follow the basic antibody antigen mechanism of action where an antibody attaches to an antig
  2. Hey CF, Try taking this regimen with the evening meal. Start with just the vitamin D3 and magnesium the first day then add the rest one day at a time until you find the culprit making you hurle... Be sure to drink at least 2.5 liters of water a day... Take care, V/R, Batch
  3. Hey Bearcat, I'll echo the welcome to Clusterbusters and add, welcome to the anti-inflammatory regimen. You're off to a good start. Be sure to start the 12-Day vitamin D3 loading schedule at 50,000 IU/day vitamin D3 for 12 days. This is the fastest way to elevate your serum 25(OH)D into the therapeutic range of 80 to 100 ng/mL which is the therapeutic range for episodic and chronic CHers to experience a favorable response to this regimen. I realize that 600,000 IU sounds like a lot of vitamin D3 for people new to vitamin D3 therapy. That said, there are several RCTs where a sin
  4. The following link to a post I made in 2012, should help explain how and why a baking soda tonic helps prevent CH. Seltzer Water and the Baking Soda Tonic both produce the same bicarbonate ion, HCO3- per the following chemical formulas, but that's where the similarity ends. Seltzer Water has a pH between 3 and 4 due to the carbonic acid formed when CO2 is dissolved in water under pressure. A solution of sodium bicarbonate (Baking Soda Tonic) has a pH of 9.3 making it far more alkaline. In fact, the carbonate concentration of the baking soda tonic is 100 times that of the carbonic acid maki
  5. Hey Dan, You can download a copy of the anti-inflammatory regimen CH preventative treatment protocol with vitamin D3 at the following link. Just paste it in your browser. http://www.vitamindwiki.com/tiki-download_wiki_attachment.php?attId=7708 It would help if you could see your PCP for a lab test of your serum 25(OH)D and discuss this regimen before starting it. That way you're both singing from the same sheet music when the lab results come back. However, as nearly all CHers in cycle have a low serum 25(OH)D concentration and it looks like obtaining this lab test will take
  6. Hey Kris, The anti-inflammatory regimen may help relieve some of the pain you experience with your constellation of headaches. All trigeminal autonomic cephalalgias (TACs) have at least two things in common... Sufferers tend to have a low vitamin D3 status from an insufficiency to a deficiency. TACs also share the same basic mechanism of action involving neruogenic inflammation and pain caused by calcitonin gene-related peptide (CGRP) and/or Substance P (SP). Please shoot me a PM so we can discuss options. In the mean time, please download a copy of the anti-inflammatory regimen tr
  7. Most readers have seen my posts about the benefits of vitamin D3 above and beyond preventing CH. Although I've discussed taking vitamin C as an adjunct to vitamin D3 in preventing CH, there's a much bigger picture in the benefits of vitamin C if we take enough. Spend five minutes watching the video at the following link. It will be well worth the time and tell you more than any post I could write. Preventing illness and disease with vitamin C. https://www.youtube.com/watch?time_continue=2&v=7kGo0DfxQss (5:21) For guests, plug the following in your browser and replace
  8. J, I totally understand your predicament. You need to be head-zup teaching class and the CH beast makes that difficult to impossible depending how ugly it jumps. It's your call on what to take to get through classes. Do what you need to do... Having the CH return at progressively higher severity attacks as you taper off the prednisone tells us you're still fighting a significant inflammation. Adding a 1000 mg tablet of vitamin C along with the Benadryl (Diphenhydramine HCL) every 4 hours has worked nicely for CHers in similar situations... A 1000 mg/day of Turmeric (Curcumin)
  9. Amon10, There's likely a good reason why 89-90% of CH attacks hit while sleeping if you're an ECHer in cycle or a CCHer... even if you're working swing or graveyard shifts. For starters, I've found several studies indicating the CH syndrome is pH sensitive. More on this later... Secondly, during sleep, our respiration rate, lung tidal volume and alveolar ventilation drop to their lowest levels while still on the good side of the air-grass barrier... Basic respiratory physiology tells us that under these conditions, our blood chemistry changes as follows: The arterial partial
  10. MG, The link you posted is to the abstract of this survey. I was posting data from a poster presentation Dr. Rozen made at the American Headache Society annual meeting in 2009. As one of the unlisted co-authors of this survey's questionnaire, I also have the raw data and took part in its analysis. The figures I posted above are as detailed and accurate as possible. I understand your comments on "Average time to correct diagnosis" but the percentages in these two responses came from two separate survey questions which account for their totals being different than what you expected.
  11. Tpos, All, Conclusions from the 2008 survey of 1134 CHers by Dr. Todd Rozen, MD FAAN, that clearly apply to this discussion: Some of the results from the United States Cluster Headache Survey provide new clinical information on the characteristics of CH. 1. Eye color is not predominantly hazel but rather blue or brown 2. Female CH patients do not have CH triggered by alcohol as frequently as men 3. Weather changes trigger CH in more than 35% of CH sufferers 4. Auras occur in about 20% of CH patients (which has been documented) but aura duration is shorter than that seen in mi
  12. Brianh. One of the best answers to your question comes from a survey of 1134 CHers conducted by Dr. Todd Rozen, M.D. FAAN October - December 2008. 1134 individuals completed the survey (816 male, 318 female). 868 patients had episodic CH (male: female 2.9:1) while 266 had chronic CH (male:female 1.8:1). A. Age of Onset: 71% had their first ever CH at 30 years of age or younger, 35% 20 years of age or younger, while 20% of CCH started after age 40 years vs 10% ECH - 45% of female CH patients had age of onset 20 yrs of age or younger vs 32% of male CH patients B. Eye Color: Pr
  13. Hey J, Off hand, I'd say you're doing great and it appears the vitamin D3 loading schedule worked as advertised. The average gain in 25(OH)D serum concentration during the vitamin D3 loading schedule is 10 to 12 ng/mL for every 100,000 IU of vitamin D3 when starting around 30 ng/mL. Using that formula, you gained roughly 78 ng/mL. Adding that to your starting 25(OH)D serum concentration, we'll assume to be 29 ng/mL we get 107 ng/mL as your new total... That's close enough. At the end of this loading schedule, we drop back to an initial maintenance dose of 10,000 IU/day. 30 days afte
  14. Brianh, Nobody knows what causes CH. Even the high priced, highly published CH expert neurologist give us the Italian salute as they're clueless when it comes to the cause of CH. Based on the feedback from several hundred CHers taking the anti-inflammatory regimen with 10,000 IU/day vitamin D3 and its cofactors to prevent their CH, I'm inclined to say a vitamin D3 deficiency plays a role in the pathogenesis of CH, but I wouldn't go so far as saying this deficiency is the cause. I do know that 83% of CHers who start this regimen experience a significant reduction in the frequency o
  15. Hey Atama, Your home oxygen therapy prescription should read "Oxygen therapy at 15 to 25 liters/minute with non-rebreather mask for cluster headache." Please let us know when you get the HOOF kit. There's a new oxygen therapy procedure that works very well and rapidly to abort your CH. You'll need it until you get started on the anti-inflammatory regimen with 10,000 IU/day vitamin D3 and the cofactors. Take care, V/R, Batch
  16. Hey Greeneyes, My hat is off to you and damn the torpedoes full speed ahead.. My wife thinks I'm crazy when she sees me sucking on oxygen during one of my 25(OH)D burn down tests... then says... "You know how to stop them so why do you keep doing this to yourself?" In reality, the few CH I do have during a 25(OH)D burn down test where I stop just the vitamin D3 until I get the first hit, I catch so early and they're so mild, I usually knock them down by hyperventilating at forced vital capacity tidal volumes with room air for 30 seconds then suck up a lungful of 100% oxygen and hold
  17. Hey Greeneyes, I'm not a physician so I don't diagnose and I do not prescribe. If you're looking for information on CH, I'll tell you what I do or what's been reported in the online survey of CHers taking the anti-inflammatory regimen... A headache lasting 30 minutes to an hour does not fit the ICH description for short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT), or short-lasting unilateral neuralgiform headache with cranial autonomic features (SUNA). That said, you could have both CH and SUNA so I give your neurologist high marks in trying
  18. Steve, Please believe me I know how you feel having broken the code so to speak with Claritin. I'm all about if it works, don't screw with it... I would suggest if you haven't already done so, is to get your wife started on the anti-inflammatory regimen. Like you, I have a wonderful supporter who has stood by me and my CH for nearly 24 years. I got her started on this regimen a little over a month after I started it in October of 2010. She had been a migraineur for more than 20 years at that point with migraines hitting for 3 to 5 days a month like clockwork. She hasn't had a single
  19. Hey Ceyron, We know what you're going through and most of us old timers like CHfather have the T-Shirts and coffee mugs from cluster headache conferences over the years to prove it. He's given you an excellent suggestion on using a freshly charged oxygen cylinder. It's also possible you're having a CGRP cascade triggered by an allergic reaction. When this happens, none of the standard CH interventions work effectively including oxygen. CHers are typically dehydrated so be sure to drink at least 2.5 liters of water a day. It also helps if you drink a glass of ice water with lots
  20. Hey Steve, Thanks for the reply and Jon, thanks for the kind words. Like you, I've had plenty of first-hand experience with Benadryl getting my CH back under control with the anti-inflammatory regimen... Steve, have you downloaded a copy of the latest version of the anti-inflammatory regimen? It contains a major section on the vitamin D3 loading schedules and allergies with the need for a first-generation antihistamine. An allergic reaction occurs when enough allergens reach a threshold and trigger mast cells to degranulate releasing histamine and a lot of other neuropeptides.
  21. Hey Steve, One question and some comments... When you started the anti-inflammatory regimen, did you also start the 12-Day vitamin D3 loading schedule at 50,000 IU/day for 12 days? Regarding taking Claritin (Loratadine)... Good move... I've been suggesting a first-generation antihistamine like Benadryl (DIphenhydramine HCL) as it passes through the blood brain barrier to block H1 histamine receptors on neuronal genes throughout the brain and in particular, the trigeminal ganglia where the neurons have a relatively high density of GCRP expressing genes. Blocking the H1 histamine re
  22. Hey Gail, Pull down a copy of the anti-inflammatory regimen with 10,000 IU/day vitamin D3 from the following link and read through it. If it looks to your liking, share a copy with your primary care physician when you ask for the lab test of your serum 25(OH)D. Please let me know if you have questions. http://www.vitamindwiki.com/tiki-download_wiki_attachment.php?attId=7708 Take care and please keep us posted. V/R, Batch
  23. xxx

    Gliacin

    No studies listed in clinicaltrials.gov for Gliacin... There were a handful of studies on Boswellia Serrata, the primary ingredient in Gliacin, but none done on headaches.. V/R, Batch
  24. Primrose, Got it and thanks for the kind words. You have my reply in your PM InBox. Please discuss it with your PCP or neurologist. Take care and hugs, V/R, Batch
  25. Hey Primrose, Dallas Denny, CHfather and Spiney have given you some great suggestions that should help to control your CH. I'm particularly interested in your case as you also have episodic migraines with aura. My wife was a migraineur for over 20 years with bouts hitting monthly for 3 to 5 days like clockwork until she started the anti-inflammatory regimen in December of 2010. She hasn't had a migraine since. I've sent you a PM with information to discuss with your PCP or neurologist. Take care and please keep us posted. V/R, Batch
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